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Cystinuria-specific rBAT(R365W) mutation reveals two translocation pathways in the amino acid transporter rBAT-b 0,+ AT

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Date

2004

Authors

Pineda, Marta
Wagner, Carsten
Broer, Angelika
Stehberger, Paul
Kaltenbach, Simone
Gaskett, Chris
Martin del Rio, Rafael
Zorzano, Antonio
Palacin, Manuel
Lang, Florian

Journal Title

Journal ISSN

Volume Title

Publisher

Portland Press

Abstract

Apical reabsorption of dibasic amino acids and cystine in kidney is mediated by the heteromeric amino acid antiporter rBAT/b0,+AT (system b0,+). Mutations in rBAT cause cystinuria type A, whereas mutations in b0,+AT cause cystinuria type B. b0,+AT is the

Description

Keywords

Keywords: Amino acids; Catalysis; Cell membranes; Dissociation; Mutagens; Plasma membrane; Biochemistry; amino acid; amino acid transporter; antiporter; arginine; leucine; lysine; mutant protein; protein rBAT; protein subunit; trypsin; unclassified drug; amino acid Antiporter; Cystinuria; Epithelial transport; Heteromeric amino acid transporter; Membrane transport; Structure-function relationship

Citation

URI

http://hdl.handle.net/1885/78147

Collections

ANU Research Publications

Source

Biochemical Journal

Type

Journal article

Book Title

Entity type

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