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Unexpected new roles for heparanase in Type 1 diabetes and immune gene regulation

Date

Authors

Freeman, Craig

Ziolkowski, Andrew

He, Y.Q.

Sutcliffe, Elissa L

Zafar, Anjum

Rao, Sudha

Simeonovic, Charmaine

Parish, Christopher

Publisher

Elsevier BV

Abstract

Heparanase (Hpse) is an endo-β-. d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS) in basement membranes (BMs) to facilitate leukocyte migration into tissues. Heparanase activity also releases HS-bound growth factors from the extra

Keywords

Keywords: free radical; heparanase; histone H3; lysine; microRNA; pi 88; animal experiment; animal model; catalysis; cell adhesion; cell death; cell invasion; cell nucleus; cell surface; cell survival; disease course; enzyme activity; female; gene control; gene tar Basement membrane; Gene transcription; Heparan sulfate; Heparanase; Leukocyte migration; Type 1 diabetes

URI

http://hdl.handle.net/1885/84666

Collections

ANU Research Publications

Source

Matrix Biology

Type

Journal article

DOI

10.1016/j.matbio.2013.02.007

Restricted until

2037-12-31

Downloads

File

Description

01_Parish_Unexpected_new_roles_for_2013.pdf (824.02 KB)