Unexpected new roles for heparanase in Type 1 diabetes and immune gene regulation

Thumbnail Image

Date

2013

Authors

Freeman, Craig
Ziolkowski, Andrew
He, Y.Q.
Sutcliffe, Elissa L
Zafar, Anjum
Rao, Sudha
Simeonovic, Charmaine
Parish, Christopher

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier BV

Abstract

Heparanase (Hpse) is an endo-β-. d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS) in basement membranes (BMs) to facilitate leukocyte migration into tissues. Heparanase activity also releases HS-bound growth factors from the extra

Description

Keywords

Keywords: free radical; heparanase; histone H3; lysine; microRNA; pi 88; animal experiment; animal model; catalysis; cell adhesion; cell death; cell invasion; cell nucleus; cell surface; cell survival; disease course; enzyme activity; female; gene control; gene tar Basement membrane; Gene transcription; Heparan sulfate; Heparanase; Leukocyte migration; Type 1 diabetes

Citation

URI

http://hdl.handle.net/1885/84666

Collections

ANU Research Publications

Source

Matrix Biology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.matbio.2013.02.007

Restricted until

2037-12-31

Downloads

File
Description
01_Parish_Unexpected_new_roles_for_2013.pdf (824.02 KB)

DSpace software copyright © 2002-2026 LYRASIS