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The investigation of interferences in immunoassay

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dc.contributor.authorWard, Greg
dc.contributor.authorSimpson, Aaron
dc.contributor.authorBoscato, Lyn
dc.contributor.authorHickman, Peter E.
dc.date.accessioned2018-01-05T03:26:56Z
dc.date.issued2017-12
dc.description.abstractImmunoassay procedures have a wide application in clinical medicine and as such are used throughout clinical biochemistry laboratories both for urgent and routine testing. Clinicians and laboratory personnel are often presented with immunoassay results which are inconsistent with clinical findings. Without a high index of suspicion interferences will often not be suspected. Artifactual results can be due to a range of interferences in immunoassays which can include cross reacting substances, heterophile antibodies, autoantibodies and the high dose hook effect. Further, pre-analytical aspects and certain disease states can influence the potential for interference in immunoassays. Practical solutions for investigation of artifactual results in the setting of the routine clinical laboratory are provided.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn0009-9120en_AU
dc.identifier.urihttp://hdl.handle.net/1885/139078
dc.provenancehttp://www.sherpa.ac.uk/romeo/issn/0009-9120/..."Author's post-print on open access repository after an embargo period of between 12 months and 48 months" from SHERPA/RoMEO site (as at 4/01/18).
dc.publisherElsevieren_AU
dc.rights© 2017 The Canadian Society of Clinical Chemistsen_AU
dc.sourceClinical biochemistryen_AU
dc.subjectartifactual resultsen_AU
dc.subjectheterophileen_AU
dc.subjecthigh-dose hooken_AU
dc.subjectimmunoassay interferenceen_AU
dc.subjectautoantibodiesen_AU
dc.subjecthumansen_AU
dc.subjectimmunoassayen_AU
dc.subjectartifactsen_AU
dc.subjectclinical laboratory techniquesen_AU
dc.titleThe investigation of interferences in immunoassayen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue18en_AU
local.bibliographicCitation.lastpage1311en_AU
local.bibliographicCitation.startpage1306en_AU
local.contributor.affiliationSimpson, A., Medical School, The Australian National Universityen_AU
local.contributor.affiliationHickman, P. E., Medical School, The Australian National Universityen_AU
local.contributor.authoruidU5087337en_AU
local.identifier.citationvolume50en_AU
local.identifier.doi10.1016/j.clinbiochem.2017.08.015en_AU
local.identifier.essn1873-2933en_AU
local.publisher.urlhttps://www.elsevier.com/en_AU
local.type.statusAccepted Versionen_AU

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