Developmental onset of functional activity in the wallaby whisker cortex in response to stimulation of the infraorbital nerve

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dc.contributor.authorMark, R F
dc.contributor.authorFlett, D
dc.contributor.authorMarotte, Lauren
dc.contributor.authorWaite, P M E
dc.date.accessioned2015-12-13T23:40:04Z
dc.date.available2015-12-13T23:40:04Z
dc.date.issued2002
dc.date.updated2015-12-12T09:27:40Z
dc.description.abstractThis study used the extrauterine development of a marsupial wallaby to investigate the onset of functional activity in the somatosensory pathway from the whiskers. In vivo recordings were made from the somatosensory cortex from postnatal day (P) 55 to P138, in response to electrical stimulation of the infraorbital nerve supplying the mystacial whiskers. Current source density analysis was used to localize the responses within the cortical depth. This was correlated with development of cortical lamination and the onset of whisker-related patches, as revealed by cytochrome oxidase. The earliest evoked activity occurred at P61, when layers 5 and 6 are present, but layer 4 has not yet developed. This activity showed no polarity reversal with depth, suggesting activity in thalamocortical afferents. By P72 synaptic responses were detected in developing layer 4 and cytochrome oxidase showed the first hint of segregation into whisker-related patches. These patches were clear by P86. The evoked response at this age showed synaptic activity first in layer 4 and then in deep layer 5/upper layer 6. With maturity, responses became longer lasting with a complex sequence of synaptic activity at different cortical depths. The onset of functional activity is coincident with development of layer 4 and the onset of whisker-related pattern formation. A similar coincidence is seen in the rat, despite the markedly different chronological timetable, suggesting similar developmental mechanisms may operate in both species.
dc.identifier.issn0899-0220
dc.identifier.urihttp://hdl.handle.net/1885/94290
dc.publisherCarfax Publishing, Taylor & Francis Group
dc.sourceSomatosensory and Motor Research
dc.subjectKeywords: cytochrome c oxidase; animal experiment; animal tissue; article; development; electrostimulation; evoked response; histochemistry; infraorbital nerve; kangaroo; nerve stimulation; newborn; nonhuman; priority journal; somatosensory cortex; vibrissa; Aging; Barrel; Evoked potential; Marsupial; Somatosensory; Trigeminal; Vibrissae
dc.titleDevelopmental onset of functional activity in the wallaby whisker cortex in response to stimulation of the infraorbital nerve
dc.typeJournal article
local.bibliographicCitation.issue3
local.bibliographicCitation.lastpage206
local.bibliographicCitation.startpage198
local.contributor.affiliationMark, R F, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationFlett, D, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMarotte, Lauren, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWaite, P M E, University of New South Wales
local.contributor.authoremailrepository.admin@anu.edu.au
local.contributor.authoruidMark, R F, u750004
local.contributor.authoruidFlett, D, u921276
local.contributor.authoruidMarotte, Lauren, u7400435
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110906 - Sensory Systems
local.identifier.ariespublicationMigratedxPub23848
local.identifier.citationvolume19
local.identifier.doi10.1080/0899022021000009116
local.identifier.scopusID2-s2.0-0036397340
local.identifier.uidSubmittedByMigrated
local.type.statusPublished Version

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