Single-molecule studies of fork dynamics in Escherichia coli DNA replication
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Authors
Tanner, Nathan A
Hamdan, Samir
Jergic, Slobodan
Loscha, Karin
Schaeffer, Patrick
Dixon, Nicholas
van Oijen, Antoine M
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Nature Publishing Group
Abstract
We present single-molecule studies of the Escherichia coli replication machinery. We visualize individual E. coli DNA polymerase III (Pol III) holoenzymes engaging in primer extension and leading-strand synthesis. When coupled to the replicative helicase
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Nature Structural and Molecular Biology
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2037-12-31