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Single-molecule studies of fork dynamics in Escherichia coli DNA replication

Date

Authors

Tanner, Nathan A

Hamdan, Samir

Jergic, Slobodan

Loscha, Karin

Schaeffer, Patrick

Dixon, Nicholas

van Oijen, Antoine M

Publisher

Nature Publishing Group

Abstract

We present single-molecule studies of the Escherichia coli replication machinery. We visualize individual E. coli DNA polymerase III (Pol III) holoenzymes engaging in primer extension and leading-strand synthesis. When coupled to the replicative helicase

Keywords

Keywords: DNA polymerase; DNA primase; DnaB helicase; holoenzyme; article; controlled study; DNA replication; Escherichia coli; nonhuman; priority journal; protein protein interaction; DNA Polymerase III; DNA Replication; DNA, Bacterial; DnaB Helicases; Endodeoxyri

URI

http://hdl.handle.net/1885/50659

Collections

ANU Research Publications

Source

Nature Structural and Molecular Biology

Type

Journal article

DOI

10.1038/nsmb.1381

Restricted until

2037-12-31

Downloads

File

Description

01_Tanner_Single-molecule_studies_of_2008.pdf (92.32 KB)

02_Tanner_Single-molecule_studies_of_2008.pdf (386.16 KB)