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Pas-de-deux: African Plasmodium falciparum adaptations to sickle hemoglobin

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Date

2022

Authors

Matuschewski, Kai
Maier, Alexander

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

The molecular arms race between humans and Plasmodium falciparum in Africa resulted in selection of sickle-cell disease, which, on balance, protects heterozygote carriers against severe malaria. Band et al. discovered that parasites counter-adapt and can overcome disease resistance by identifying parasite genome signatures, termed P. falciparum sickle-associated (Pfsa) variants.

Description

Keywords

Citation

URI

http://hdl.handle.net/1885/293694

Collections

ANU Research Publications

Source

Trends in Parasitology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.pt.2022.01.009

Restricted until

2099-12-31

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1-s2.0-S1471492222000101-main.pdf (447.16 KB)

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