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Sex from W to Z - evolution of vertebrate sex chromosomes and sex determining genes

Date

2001

Authors

Graves, Jennifer
Shetty, Swathi

Journal Title

Journal ISSN

Volume Title

Publisher

John Wiley & Sons Inc

Abstract

Sex determination in major vertebrate groups appears to be very variable, including systems of male heterogamety, female heterogamety and a variety of genetic and environmental sex determining systems. Yet comparative studies of sex chromosomes and sex determining genes now suggest that these differences are more apparent than real. The sex chromosomes of even widely divergent groups now appear to have changed very little over the last 300+ million years, and even independently derived sex chromosomes seem to have followed the same set of evolutionary rules. The sex determining pathway seems to be extremely conserved, although the control of the genes in this pathway is vested in different elements. We present a scenario for the independent evolution of XY male heterogamety in mammals and ZW female heterogamety in birds and some reptiles. We suggest that sex determining genes can be made redundant, and replaced by control at another step of a conserved sex determining pathway, and how choice of a gene as a sex switch has led to the evolution of new sex chromosome systems.

Description

Keywords

animal, bird, conference paper, female, gender and sex, male, mammal, molecular evolution, reptile, sex chromosome, vertebrate, Animals, Animals, Birds, Evolution, Molecular, Female

Citation

Source

Journal of Experimental Zoology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1002/jez.1088

Restricted until

2099-12-31