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A novel β-oxa polyunsaturated fatty acid downregulates the activation of the IκB kinase/nuclear factor κB pathway, inhibits expression of endothelial cell adhesion molecules, and depresses inflammation

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Date

2006

Authors

Ferrante, Antonio
Robinson, Brenton S
Singh, Harmeet
Jersmann, Herbertus
Ferrante, Judith V
Huang, Zhi H
Trout, Neil A
Pitt, Michael J
Rathjen, Deborah A
Easton, Christopher

Journal Title

Journal ISSN

Volume Title

Publisher

Lippincott Williams & Wilkins

Abstract

Several novel polyunsaturated fatty acids (PUFAs) that contain either an oxygen or sulfur atom in the β-position were found to exhibit more selective antiinflammatory properties than their natural PUFA counterparts. One of these, β-oxa-23:4n-6, unlike n

Description

Keywords

Keywords: cell adhesion molecule; endothelial leukocyte adhesion molecule 1; I kappa B kinase; immunoglobulin enhancer binding protein; mitogen activated protein kinase; polyunsaturated fatty acid; tumor necrosis factor alpha; vascular adhesion protein 1; antiinfla Adhesion molecules; Endothelial cells; Lipoxygenase; Long chain fatty acids; NF-?B

Citation

URI

http://hdl.handle.net/1885/84977

Collections

ANU Research Publications

Source

Circulation Research

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1161/01.RES.0000231292.66084.cd

Restricted until

2037-12-31

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