A novel β-oxa polyunsaturated fatty acid downregulates the activation of the IκB kinase/nuclear factor κB pathway, inhibits expression of endothelial cell adhesion molecules, and depresses inflammation

Ferrante, Antonio; Robinson, Brenton S; Singh, Harmeet; Jersmann, Herbertus; Ferrante, Judith V; Huang, Zhi H; Trout, Neil A; Pitt, Michael J; Rathjen, Deborah A; Easton, Christopher; Poulos, Alf; Prager, Rolf H; Lee, Frank S; Hii, Charles

A novel β-oxa polyunsaturated fatty acid downregulates the activation of the IκB kinase/nuclear factor κB pathway, inhibits expression of endothelial cell adhesion molecules, and depresses inflammation

Date

2006

Authors

Ferrante, Antonio

Robinson, Brenton S

Singh, Harmeet

Jersmann, Herbertus

Ferrante, Judith V

Huang, Zhi H

Trout, Neil A

Pitt, Michael J

Rathjen, Deborah A

Easton, Christopher

Publisher

Lippincott Williams & Wilkins

Abstract

Several novel polyunsaturated fatty acids (PUFAs) that contain either an oxygen or sulfur atom in the β-position were found to exhibit more selective antiinflammatory properties than their natural PUFA counterparts. One of these, β-oxa-23:4n-6, unlike n