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Defective T-cell function leading to reduced antibody production in a kleisin-beta mutant mouse

Date

Authors

Gosling, Katharine

Goodnow, Christopher

Verma, Naresh

Fahrer, Aude

Publisher

Blackwell Publishing Ltd

Abstract

The recently described nessy (Ncaph2nes/nes) mutant mouse strain has a defect in T-cell development caused by a mutation in the ubiquitous kleisin-β (also known as Ncaph2). Kleisin-β is a subunit of the condensin II complex involved in chromosome conden

Keywords

Keywords: beta kleisin; condensin; unclassified drug; animal cell; animal experiment; animal model; antibody production; antibody response; antibody titer; article; B lymphocyte; CD4+ T lymphocyte; CD8+ T lymphocyte; cell function; cell maturation; cell proliferati Kleisin; Ncaph2; Salmonella; T-cell activation; T-cell-dependent antibody

URI

http://hdl.handle.net/1885/30054

Collections

ANU Research Publications

Source

Immunology

Type

Journal article

DOI

10.1111/j.1365-2567.2008.02831.x

Restricted until

2037-12-31

Downloads

File

Description

01_Gosling_Defective_T-cell_function_2008.pdf (339.63 KB)