Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit

Schedlich, Lynette; Le Page, Sophie; Firth, Sue M; Briggs, Lyndall; Jans, David A; Baxter, Rohan

Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit

Date

2000

Authors

Schedlich, Lynette

Le Page, Sophie

Firth, Sue M

Briggs, Lyndall

Jans, David A

Baxter, Rohan

Publisher

American Society for Biochemistry and Molecular Biology Inc

Abstract

Although insulin-like growth factor-binding protein (IGFBP)-3 and IGFBP-5 are known to modulate cell growth by reversibly sequestering extracellular insulin-like growth factors, several reports have suggested that IGFBP-3, and possibly also IGFBP-5, have