A variably spliced region in the type 1 ryanodine receptor may participate in an inter-domain interaction
Date
2007
Authors
Kimura, Takashi
Pace, Suzy M
Wei, Lan
Beard, Nicole
Dirksen, Robert
Dulhunty, Angela
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Publisher
Portland Press
Abstract
The aim of the present study was to examine residues that are variably spliced in the juvenile and adult isoforms of the skeletal-muscle RyR1 (type 1 ryanodine receptor). The juvenile ASI(-) splice variant is less active than the adult ASI(+) variant and
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Keywords
Keywords: Binding partners; Juvenile isoform; Ryanodine binding; Sarcoplasmic reticulum vesicles; Blood vessels; Muscle; Proteins; Biochemistry; binding protein; glycine; isoprotein; peptide pasi; ryanodine receptor 1; threonine; tritium; unclassified drug; alterna Alternative splicing; Inter-domain interaction; Myotonic dystrophy; Single channel recording; Skeletal ryanodine receptor; Synthetic peptide
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Source
Biochemical Journal
Type
Journal article
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Restricted until
2037-12-31
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