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CTLA-4 and its role in autoimmune thyroid disease

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Date

2003

Authors

Chistiakov, D A
Turakulov, R

Journal Title

Journal ISSN

Volume Title

Publisher

Society for Endocrinology

Abstract

Autoimmune thyroid disease (AITD) occurs in two common forms: Graves' disease and Hashimoto thyroiditis. On the basis of functional and experimental data, it has been suggested that the gene encoding cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a candidate gene for conferring susceptibility to thyroid autoimmunity. In this review, we critically evaluate the evidence for pathogenetic involvement of CTLA-4 in the various forms of AITD and focus on the possible role of genetic variation of the CTLA4 locus. Population genetics data strongly suggest a role for the CTLA4 region in susceptibility to AITD. However, further functional studies are required to understand the significance of CTLA4 polymorphisms in the pathogenic mechanism of AITD.

Description

Keywords

Keywords: cytotoxic T lymphocyte antigen 4; autoimmune disease; gene locus; genetic code; genetic polymorphism; genetic susceptibility; genetic variability; Graves disease; Hashimoto disease; human; nonhuman; pathogenesis; population genetics; priority journal; rev

Citation

URI

http://hdl.handle.net/1885/86601

Collections

ANU Research Publications

Source

Journal of Molecular Endocrinology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1677/jme.0.0310021

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