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Harnessing CRISPR-Cas system diversity for gene editing technologies

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dc.contributor.authorMcKay, Alexander
dc.contributor.authorBurgio, Gaetan
dc.date.accessioned2023-08-16T02:13:02Z
dc.date.available2023-08-16T02:13:02Z
dc.date.issued2021
dc.date.updated2022-07-24T08:18:47Z
dc.description.abstractThe discovery and utilization of RNA-guided surveillance complexes, such as CRISPR-Cas9, for sequencespecific DNA or RNA cleavage, has revolutionised the process of gene modification or knockdown. To optimise the use of this technology, an exploratory race has ensued to discover or develop new RNA-guided endonucleases with the most flexible sequence targeting requirements, coupled with high cleavage efficacy and specificity. Here we review the constraints of existing gene editing and assess the merits of exploiting the diversity of CRISPR-Cas effectors as a methodology for surmounting these limitations.en_AU
dc.description.sponsorshipGaetan Burgio is supported by the National Collaborative Research Infrastructure (NCRIS) via Phenomics Australia, the National Health and Medical Research Council of Australia (Grant No. APP1143008), the Australian Research Council (Grant No. DP180101494) and the National Natural Science Foundation of China (Grant No. 81772214).en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn1674-8301en_AU
dc.identifier.urihttp://hdl.handle.net/1885/295613
dc.language.isoen_AUen_AU
dc.provenanceThis is an open access article under the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited.en_AU
dc.publisherNanjing Yike Daxueen_AU
dc.relationhttp://purl.org/au-research/grants/arc/DP180101494en_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1143008en_AU
dc.rights© 2021 by the Journal of Biomedical Research.en_AU
dc.rights.licenseCreative Commons Attribution 4.0 International Licenseen_AU
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_AU
dc.sourceJournal of Biomedical Researchen_AU
dc.subjectCRISPR-Cas systemsen_AU
dc.subjectgene editingen_AU
dc.subjectbiological evolutionen_AU
dc.subjectDNA repairen_AU
dc.subjectclassificationen_AU
dc.subjectDNA transposable elementsen_AU
dc.titleHarnessing CRISPR-Cas system diversity for gene editing technologiesen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue2en_AU
local.bibliographicCitation.lastpage106en_AU
local.bibliographicCitation.startpage91en_AU
local.contributor.affiliationMcKay, Alexander, College of Health and Medicine, ANUen_AU
local.contributor.affiliationBurgio, Gaetan, College of Health and Medicine, ANUen_AU
local.contributor.authoruidMcKay, Alexander, u5581638en_AU
local.contributor.authoruidBurgio, Gaetan, u5727247en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor320601 - Gene and molecular therapyen_AU
local.identifier.absfor310113 - Synthetic biologyen_AU
local.identifier.absfor320603 - Medical molecular engineering of nucleic acids and proteinsen_AU
local.identifier.absseo240803 - Human pharmaceutical treatmentsen_AU
local.identifier.absseo200105 - Treatment of human diseases and conditionsen_AU
local.identifier.absseo280103 - Expanding knowledge in the biomedical and clinical sciencesen_AU
local.identifier.ariespublicationa383154xPUB19451en_AU
local.identifier.citationvolume35en_AU
local.identifier.doi10.7555/JBR.35.20200184en_AU
local.identifier.scopusID2-s2.0-85104786744
local.identifier.thomsonIDWOS:000657161300003
local.publisher.urlhttp://www.jbr-pub.org.cn/en_AU
local.type.statusPublished Versionen_AU

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