Mutations on the N-terminal edge of the DELSEED loop in either the α or β subunit of the mitochondrial F 1 -ATPase enhance ATP hydrolysis in the absence of the central γ rotor

Abstract

F1-ATPase is a rotary molecular machine with a subunit stoichiometry of α3 β3 γ1 δ1 ε1. It has a robust ATP-hydrolyzing activity due to effective cooperativity between the three catalytic sites. It is believed that the central γ rotor dictates the s Show more