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Polymorphisms in the human glutathione transferase Kappa (GSTK1) promoter alter gene expression

Date

Authors

Shield, Alison

Murray, Tracy

Cappello, Jean

Coggan, Marjorie

Board, Philip

Publisher

Academic Press

Abstract

The level of glutathione transferase Kappa (GSTK1-1) has been correlated with obesity (Liu et.al. 2008 PNAS 105: 18302-7) and a polymorphism in the hGSTK1 promoter has been associated with insulin secretion and fat deposition (Gao et al 2009 Endocr J 56:

Keywords

Keywords: glutathione transferase; glutathione transferase kappa; retinoid X receptor; unclassified drug; article; binding site; DNA flanking region; DNA polymorphism; exon; gene expression; gene repression; human; human cell; insulin release; intron; lipid storage Glutathione transferase Kappa; Promoter; Single nucleotide polymorphisms

URI

http://hdl.handle.net/1885/18725

Collections

ANU Research Publications

Source

Genomics

Type

Journal article

DOI

10.1016/j.ygeno.2010.02.007

Restricted until

2037-12-31

Downloads

File

Description

01_Shield_Polymorphisms_in_the_human_2010.pdf (513.09 KB)