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The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin

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dc.contributor.authorMackay, Laura K
dc.contributor.authorRahimpour, Azad
dc.contributor.authorMa, Joel Z
dc.contributor.authorCollins, Nicholas
dc.contributor.authorStock, Angus T
dc.contributor.authorHafon, Ming-Li
dc.contributor.authorVega-Ramos, Javier
dc.contributor.authorLauzurica, Pilar
dc.contributor.authorMueller, Scott N
dc.contributor.authorStefanovic, Tijana
dc.contributor.authorTscharke, David C
dc.contributor.authorHeath, William R
dc.contributor.authorInouye, Michael
dc.contributor.authorCarbone, Francis R
dc.contributor.authorGebhardt, Thomas
dc.date.accessioned2015-03-12T23:13:28Z
dc.date.available2015-03-12T23:13:28Z
dc.date.issued2013-10-10
dc.date.updated2015-12-11T09:08:05Z
dc.description.abstractTissue-resident memory T cells (T(RM) cells) provide superior protection against infection in extralymphoid tissues. Here we found that CD103(+)CD8(+) T(RM) cells developed in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1. A combination of entry into the epithelium plus local signaling by interleukin 15 (IL-15) and transforming growth factor-β (TGF-β) was required for the formation of these long-lived memory cells. Notably, differentiation into T(RM) cells resulted in the progressive acquisition of a unique transcriptional profile that differed from that of circulating memory cells and other types of T cells that permanently reside in skin epithelium. We provide a comprehensive molecular framework for the local differentiation of a distinct peripheral population of memory cells that forms a first-line immunological defense system in barrier tissues.
dc.description.sponsorshipSupported by National Health and Medical Research Council of Australia and Australian Research Council.en_AU
dc.identifier.issn1529-2908
dc.identifier.urihttp://hdl.handle.net/1885/12900
dc.publisherNature Publishing Group
dc.relationhttp://purl.org/au-research/grants/nhmrc/1005846
dc.rightshttp://www.sherpa.ac.uk/romeo/issn/1529-2908/..."Authors retain copyright, Author's pre-print on arXiv or bioRXiv, Author's post-print on author's personal website, institutional repository, PubMed Central or funding body's archive, Published source must be acknowledged, Must link to publisher version with DOI, Publisher's version/PDF cannot be used" from SHERPA/RoMEO site (as at 23/03/15)
dc.sourceNature immunology
dc.subjectAnimals
dc.subjectAntigens, CD
dc.subjectAntigens, Differentiation, T-Lymphocyte
dc.subjectCD8-Positive T-Lymphocytes
dc.subjectCell Differentiation
dc.subjectFlow Cytometry
dc.subjectHerpes Simplex
dc.subjectHerpesvirus 1, Human
dc.subjectHost-Pathogen Interactions
dc.subjectImmunologic Memory
dc.subjectIntegrin alpha Chains
dc.subjectInterleukin-15
dc.subjectLectins, C-Type
dc.subjectMice
dc.subjectMice, Inbred C57BL
dc.subjectMice, Inbred Strains
dc.subjectMice, Knockout
dc.subjectMice, Transgenic
dc.subjectOligonucleotide Array Sequence Analysis
dc.subjectProtein-Serine-Threonine Kinases
dc.subjectReceptors, Immunologic
dc.subjectReceptors, Transforming Growth Factor beta
dc.subjectReverse Transcriptase Polymerase Chain Reaction
dc.subjectSignal Transduction
dc.subjectSkin
dc.subjectTranscriptome
dc.titleThe developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin
dc.typeJournal article
dcterms.dateAccepted2013-09-20
local.bibliographicCitation.issue12en_AU
local.bibliographicCitation.lastpage1301en_AU
local.bibliographicCitation.startpage1294en_AU
local.contributor.affiliationStefanovic, T., Research School of Biology, The Australian National Universityen_AU
local.contributor.affiliationTscharke, D. C. Research School of Biology, The Australian National Universityen_AU
local.contributor.authoruidu4334102en_AU
local.identifier.absfor110700 - IMMUNOLOGY
local.identifier.ariespublicationf5625xPUB4690
local.identifier.citationvolume14en_AU
local.identifier.doi10.1038/ni.2744en_AU
local.identifier.essn1529-2916en_AU
local.identifier.scopusID2-s2.0-84888008030
local.identifier.thomsonID000327149400015
local.publisher.urlhttp://www.nature.com/en_AU
local.type.statusSubmitted Versionen_AU

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