IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection

Simple item page
dc.contributor.authorWang, Huimeng
dc.contributor.authorKjer-Nielsen, Lars
dc.contributor.authorShi, Mai
dc.contributor.authorD'Souza, Criselle
dc.contributor.authorPediongco, Troi J.
dc.contributor.authorCao, Hanwei
dc.contributor.authorKostenko, Lyudmila
dc.contributor.authorLim, Xin Yi
dc.contributor.authorEckle, Sidonia BG
dc.contributor.authorMeehan, Bronwyn
dc.contributor.authorYu, Di
dc.date.accessioned2022-12-01T00:41:29Z
dc.date.issued2019
dc.date.updated2021-11-28T07:30:29Z
dc.description.abstractMucosal-associated invariant T (MAIT) cells are activated in a TCR-dependent manner by antigens derived from the riboflavin synthesis pathway, including 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU), bound to MHC-related protein-1 (MR1). However, MAIT cell activation in vivo has not been studied in detail. Here, we have found and characterized additional molecular signals required for optimal activation and expansion of MAIT cells after pulmonary Legionella or Salmonella infection in mice. We show that either bone marrow–derived APCs or non–bone marrow–derived cells can activate MAIT cells in vivo, depending on the pathogen. Optimal MAIT cell activation in vivo requires signaling through the inducible T cell costimulator (ICOS), which is highly expressed on MAIT cells. Subsequent expansion and maintenance of MAIT-17/1-type responses are dependent on IL-23. Vaccination with IL-23 plus 5-OP-RU augments MAIT cell–mediated control of pulmonary Legionella infection. These findings reveal cellular and molecular targets for manipulating MAIT cell function under physiological conditions.en_AU
dc.description.sponsorshipH.W. was supported by a Melbourne International Engagement Award (The University of Melbourne). C.D. was supported by a Melbourne International Research Scholarship and a Melbourne International Fee Remission Scholarship (The University of Melbourne)en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2470-9468en_AU
dc.identifier.urihttp://hdl.handle.net/1885/281446
dc.language.isoen_AUen_AU
dc.publisherAmerican Association for the Advancement of Scienceen_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1113293en_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1092262en_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1120467en_AU
dc.relationhttp://purl.org/au-research/grants/arc/DP170104321en_AU
dc.relationhttp://purl.org/au-research/grants/arc/FT160100083en_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1117017en_AU
dc.relationhttp://purl.org/au-research/grants/arc/FT160100049en_AU
dc.rights© 2019 The authorsen_AU
dc.sourceScience Immunologyen_AU
dc.titleIL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infectionen_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.issue41en_AU
local.contributor.affiliationWang, Huimeng, University of Melbourneen_AU
local.contributor.affiliationKjer-Nielsen, Lars, University of Melbourneen_AU
local.contributor.affiliationShi, Mai, University of Melbourneen_AU
local.contributor.affiliationD'Souza, Criselle, University of Melbourneen_AU
local.contributor.affiliationPediongco, Troi J., University of Melbourneen_AU
local.contributor.affiliationCao, Hanwei, University of Melbourneen_AU
local.contributor.affiliationKostenko, Lyudmila, University of Melbourneen_AU
local.contributor.affiliationLim, Xin Yi, University of Melbourneen_AU
local.contributor.affiliationEckle, Sidonia BG, University of Melbourneen_AU
local.contributor.affiliationMeehan, Bronwyn, University of Melbourneen_AU
local.contributor.affiliationYu, Di, College of Health and Medicine, ANUen_AU
local.contributor.authoremailu2506956@anu.edu.auen_AU
local.contributor.authoruidYu, Di, u2506956en_AU
local.description.embargo2099-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor320405 - Humoural immunology and immunochemistryen_AU
local.identifier.absfor320404 - Cellular immunologyen_AU
local.identifier.absseo200104 - Prevention of human diseases and conditionsen_AU
local.identifier.ariespublicationu3102795xPUB5494en_AU
local.identifier.citationvolume4en_AU
local.identifier.doi10.1126/sciimmunol.aaw0402en_AU
local.identifier.scopusID2-s2.0-85075114723
local.identifier.uidSubmittedByu3102795en_AU
local.publisher.urlhttps://www.science.org/en_AU
local.type.statusPublished Versionen_AU

Downloads

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
IL-23 costimulates.pdf
Size:
839.48 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

ANU Research Publications

DSpace software copyright © 2002-2024 LYRASIS