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Age-related macular degeneration in a randomized controlled trial of low-dose aspirin: Rationale and study design of the ASPREE-AMD study

dc.contributor.authorRobman, Liubov
dc.contributor.authorGuymer, Robyn
dc.contributor.authorWoods, Robyn
dc.contributor.authorWard, Stephanie
dc.contributor.authorWolfe, Rory
dc.contributor.authorPhung, James
dc.contributor.authorHodgson, Lauren
dc.contributor.authorMakeyeva, Galina
dc.contributor.authorAung, Khin Zaw
dc.contributor.authorGilbert, Tom
dc.contributor.authorAbhayaratna, Walter
dc.date.accessioned2021-05-05T23:49:28Z
dc.date.available2021-05-05T23:49:28Z
dc.date.issued2017
dc.date.updated2020-11-23T10:10:09Z
dc.description.abstractAlthough aspirin therapy is used widely in older adults for prevention of cardiovascular disease, its impact on the incidence, progression and severity of age-related macular degeneration (AMD) is uncertain. The effect of low-dose aspirin on the course of AMD will be evaluated in this clinical trial. A sub-study of the ‘ASPirin in Reducing Events in the Elderly’ (ASPREE) trial, ASPREE-AMD is a 5-year follow-up double-blind, placebo-controlled, randomized trial of the effect of 100 mg daily aspirin on the course of AMD in 5000 subjects aged 70 years or older, with normal cognitive function and without cardiovascular disease at baseline. Non-mydriatic fundus photography will be performed at baseline, 3-year and 5-year follow-up to determine AMD status.en_AU
dc.description.sponsorshipThe principal ASPREE study has been supported by the National Health and Medical Research Council, Australia (NHMRC) [grant #334047], the National Institutes of Health (NIH) through the National Institute on Aging [grant #RO1-AG029824], the Victorian Cancer Agency (Victorian Government, Australia) and Monash University.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2451-8654en_AU
dc.identifier.urihttp://hdl.handle.net/1885/232468
dc.language.isoen_AUen_AU
dc.provenanceThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en_AU
dc.publisherElsevier Inc.en_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/334047en_AU
dc.rights© 2017 The Authors. Published by Elsevier Inc.en_AU
dc.rights.licenseCC BY-NC-ND licenseen_AU
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_AU
dc.sourceContemporary Clinical Trials Communicationsen_AU
dc.titleAge-related macular degeneration in a randomized controlled trial of low-dose aspirin: Rationale and study design of the ASPREE-AMD studyen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.lastpage114en_AU
local.bibliographicCitation.startpage105en_AU
local.contributor.affiliationRobman, Liubov, Monash Universityen_AU
local.contributor.affiliationGuymer, Robyn, Centre for Eye Research Australiaen_AU
local.contributor.affiliationWoods, Robyn, Monash Universityen_AU
local.contributor.affiliationWard, Stephanie, Monash Universityen_AU
local.contributor.affiliationWolfe, Rory, Monash Universityen_AU
local.contributor.affiliationPhung, James, Monash Universityen_AU
local.contributor.affiliationHodgson, Lauren, Centre for Eye Research Australia (CERA) - Retinal Vascular Imaging Centreen_AU
local.contributor.affiliationMakeyeva, Galina, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourneen_AU
local.contributor.affiliationAung, Khin Zaw, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourneen_AU
local.contributor.affiliationGilbert, Tom, Monash Universityen_AU
local.contributor.affiliationAbhayaratna, Walter, College of Health and Medicine, ANUen_AU
local.contributor.authoruidAbhayaratna, Walter, u3379649en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor111706 - Epidemiologyen_AU
local.identifier.ariespublicationa383154xPUB5839en_AU
local.identifier.citationvolume6en_AU
local.identifier.doi10.1016/j.conctc.2017.03.005en_AU
local.identifier.scopusID2-s2.0-85018488495
local.publisher.urlhttps://www.elsevier.com/en-auen_AU
local.type.statusPublished Versionen_AU

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