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In vivo imaging of CD8+ T cell-mediated elimination of malaria liver stages

Date

Authors

Cockburn, Ian

Amino, Rogerio

Kelemen, Reka K

Kuo, Scot C

Tse, Sze-Wah

Radtke, Andrea

Mac-Daniel, Laura

Ganusov, Vitaly V

Zavala, Fidel

Menard, Robert

Publisher

National Academy of Sciences (USA)

Abstract

CD8+ T cells are specialized cells of the adaptive immune system capable of finding and eliminating pathogen-infected cells. To date it has not been possible to observe the destruction of any pathogen by CD8+ T cells in vivo. Here we demonstrate a techniq

Keywords

Keywords: epitope; G protein coupled receptor; T lymphocyte receptor; animal cell; animal experiment; animal model; article; CD8+ T lymphocyte; cell killing; controlled study; data analysis; imaging and display; in vivo study; liver cell; malaria; mathematical mode Immunity; Lymphocytes; Plasmodium

URI

http://hdl.handle.net/1885/33017

Collections

ANU Research Publications

Source

PNAS - Proceedings of the National Academy of Sciences of the United States of America

Type

Journal article

Access Statement

Open Access

DOI

10.1073/pnas.1303858110

Downloads

File

Description

01_Cockburn_In_vivo_imaging_of_CD8+_T_2013.pdf (933.79 KB)