Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells

Date

Authors

Sun, Ramon

Board, Philip

Blackburn, Anneke

Publisher

American Association for Cancer Research

Abstract

Background: Cancer cells have a different metabolic profile compared to normal cells. The Warburg effect (increased aerobic glycolysis) and glutaminolysis (increased mitochondrial activity from glutamine catabolism) are well known hallmarks of cancer and

Keywords

Keywords: adenosine triphosphate; arsenic trioxide; cytochrome c oxidase; dichloroacetic acid; hypoxia inducible factor 1alpha; Myc protein; proton transporting adenosine triphosphatase; reactive oxygen metabolite; adenosine triphosphate; antineoplastic agent; arse Arsenic trioxide; Breast cancer; Dichloroacetate; Electron transport chain; Mitochondria

URI

http://hdl.handle.net/1885/54201

Collections

ANU Research Publications

Source

Molecular Cancer Therapeutics

Type

Journal article

DOI

10.1186/1476-4598-10-142

Restricted until

2037-12-31

Downloads

File

Description

01_Sun_Targeting_metabolism_with_2011.pdf (3.89 MB)