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Midbrain cleft as a cause of chronic internuclear ophthalmoplegia, progressive ataxia, and facial weakness

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dc.contributor.authorAhmad, Omar
dc.contributor.authorReddel, Stephen
dc.contributor.authorLueck, Christian
dc.date.accessioned2015-12-10T23:15:58Z
dc.date.issued2010
dc.date.updated2016-02-24T08:08:10Z
dc.description.abstractA 44-year-old man with progressive ataxia, facial weakness, bilateral adduction deficits, and abducting nystagmus was initially misdiagnosed and treated for multiple sclerosis because a midbrain anatomic cleft had been overlooked on brain MRI. Six cases of "midbrain (or mesencephalic) cleft" or "keyhole aqueduct syndrome" have been previously reported. This developmental anatomic abnormality always manifests bilateral internuclear ophthalmoplegia (INO), often together with ataxia, which may be progressive and debilitating. Because the INO is chronic, patients may have no visual symptoms. The cause of a midbrain cleft is uncertain, but it may be the midbrain version of a syrinx. There is no known effective treatment.
dc.identifier.issn1070-8022
dc.identifier.urihttp://hdl.handle.net/1885/64866
dc.publisherLippincott Williams & Wilkins
dc.sourceJournal of Neuro-Ophthalmology
dc.subjectKeywords: adduction; adult; article; ataxia; brain aqueduct; brain malformation; brain ventricle; case report; cervical spinal cord; diagnostic error; disease course; divergent strabismus; eye movement; facial nerve paralysis; falling; follow up; human; internuclea
dc.titleMidbrain cleft as a cause of chronic internuclear ophthalmoplegia, progressive ataxia, and facial weakness
dc.typeJournal article
local.bibliographicCitation.issue2
local.bibliographicCitation.lastpage149
local.bibliographicCitation.startpage145
local.contributor.affiliationAhmad, Omar, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationReddel, Stephen, University of Sydney
local.contributor.affiliationLueck, Christian, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidAhmad, Omar, a293887
local.contributor.authoruidLueck, Christian, u1807496
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor110904 - Neurology and Neuromuscular Diseases
local.identifier.ariespublicationf2965xPUB1011
local.identifier.citationvolume30
local.identifier.doi10.1097/WNO.0b013e3181da2ceb
local.identifier.scopusID2-s2.0-77953650128
local.identifier.thomsonID000278372400008
local.type.statusPublished Version

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