Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study

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dc.contributor.authorMcNeil, John J.
dc.contributor.authorWoods, Robyn
dc.contributor.authorNelson, Mark
dc.contributor.authorMurray, Anne M.
dc.contributor.authorReid, Christopher M.
dc.contributor.authorKirpach, Brenda
dc.contributor.authorStorey, Elsdon
dc.contributor.authorShah, Raj C.
dc.contributor.authorWolfe, Rory
dc.contributor.authorTonkin, Andrew
dc.contributor.authorAbhayaratna, Walter
dc.date.accessioned2020-12-20T20:51:45Z
dc.date.available2020-12-20T20:51:45Z
dc.date.issued2017
dc.date.updated2020-11-23T10:14:50Z
dc.description.abstractBackground There are no primary prevention trials of aspirin with relevant geriatric outcomes in elderly people. ASPirin in Reducing Events in the Elderly (ASPREE) is a placebo-controlled trial of low-dose aspirin that will determine whether 5 years of daily 100-mg enteric-coated aspirin extends disability-free and dementia-free life in a healthy elderly population and whether these benefits outweigh the risks. Methods Set in primary care, this randomized double-blind placebo-controlled trial has a composite primary endpoint of death, incident dementia or persistent physical disability. Participants aged 70+ years (non-minorities) or 65+ years (U.S. minorities) were free of cardiovascular disease, dementia, or physical disability and without a contraindication to, or indication for, aspirin. Baseline data include physical and lifestyle, personal and family medical history, hemoglobin, fasting glucose, creatinine, lipid panel, urinary albumin:creatinine ratio, cognition (3MS, HVLT-R, COWAT, SDMT), mood (CES-D-10), physical function (gait speed, grip strength), Katz activities of daily living and quality of life (SF-12). Results Recruitment ended in December 2014 with 16,703 Australian and 2,411 U.S. participants, a median age of 74 (range 65–98) years and 56% women. Approximately 55% of the U.S. cohort were from minority groups; 9% of the total cohort. Proportions with hypertension, overweight, and chronic kidney disease were similar to age-matched populations from both countries although lower percentages had diabetes, dyslipidemia, and osteoarthritis. Discussion Findings from ASPREE will be generalizable to a healthier older population in both countries and will assess whether the broad benefits of daily low-dose aspirin in prolonging independent life outweigh the risks.
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn1079-5006
dc.identifier.urihttp://hdl.handle.net/1885/217876
dc.language.isoen_AUen_AU
dc.publisherOxford University Press
dc.sourceJournals of Gerontology Series A: Biological Sciences and Medical Sciences
dc.titleBaseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study
dc.typeJournal article
local.bibliographicCitation.issue11
local.bibliographicCitation.lastpage1593
local.bibliographicCitation.startpage1586
local.contributor.affiliationMcNeil, John J, Monash University
local.contributor.affiliationWoods, Robyn, Monash University
local.contributor.affiliationNelson, Mark, University of Tasmania
local.contributor.affiliationMurray, Anne M., University of Minnesota
local.contributor.affiliationReid, Christopher M, Monash University
local.contributor.affiliationKirpach, Brenda, Hennepin County Medical Center
local.contributor.affiliationStorey, Elsdon, Monash University
local.contributor.affiliationShah, Raj C., Rush University Medical Center
local.contributor.affiliationWolfe, Rory, Monash University
local.contributor.affiliationTonkin, Andrew, Monash University
local.contributor.affiliationAbhayaratna, Walter, College of Health and Medicine, ANU
local.contributor.authoremailu3379649@anu.edu.au
local.contributor.authoruidAbhayaratna, Walter, u3379649
local.description.notesImported from ARIES
local.identifier.absfor119999 - Medical and Health Sciences not elsewhere classified
local.identifier.ariespublicationu4351680xPUB463
local.identifier.citationvolume72
local.identifier.doi10.1093/gerona/glw342
local.identifier.scopusID2-s2.0-85032643637
local.identifier.uidSubmittedByu4351680
local.type.statusPublished Version

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