Efflux of a range of antimalarial drugs and 'chloroquine resistance reversers' from the digestive vacuole in malaria parasites with mutant PfCRT

Lehane, Adele; Kirk, Kiaran

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Efflux of a range of antimalarial drugs and 'chloroquine resistance reversers' from the digestive vacuole in malaria parasites with mutant PfCRT

Date

2010

Authors

Lehane, Adele

Kirk, Kiaran

Publisher

Blackwell Publishing Ltd

Abstract

Chloroquine-resistant malaria parasites (Plasmodium falciparum) show an increased leak of H+ ions from their internal digestive vacuole in the presence of chloroquine. This phenomenon has been attributed to the transport of chloroquine, together with H+,