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Chemoenzymatic approaches to the montanine alkaloids: a total synthesis of (+)-brunsvigine

Date

Authors

Banwell, Martin

Kokas, Okanya

Willis, Anthony

Publisher

American Chemical Society

Abstract

The readily available and enzymatically derived cis-1,2-dihydrocatechols 3a and 3b have been elaborated over 17 steps, including a novel radical addition/elimination sequence, into the enantiomer, (+)-1, of the montanine alkaloid brunsvigine [(-)-1].

Keywords

Keywords: alkaloid; Amaryllidaceae alkaloid; brunsvigine; catechol derivative; isoquinoline derivative; montanine; unclassified drug; article; chemical structure; chemistry; stereoisomerism; synthesis; Alkaloids; Amaryllidaceae Alkaloids; Catechols; Isoquinolines;

URI

http://hdl.handle.net/1885/33228

Collections

ANU Research Publications

Source

Organic Letters

Type

Journal article

DOI

10.1021/ol071344y

Restricted until

2037-12-31

Downloads

File

Description

01_Banwell_Chemoenzymatic_approaches_to_2007.pdf (69.16 KB)