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Therapeutic Approaches Targeting MYC-Driven Prostate Cancer

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dc.contributor.authorRebello, Richard J
dc.contributor.authorPearson, Richard B
dc.contributor.authorHannan, Ross
dc.contributor.authorFuric, Luc
dc.date.accessioned2021-10-06T03:08:03Z
dc.date.available2021-10-06T03:08:03Z
dc.date.issued2017
dc.date.updated2020-11-23T11:21:42Z
dc.description.abstractThe transcript encoding the proto-oncogene MYC is commonly overexpressed in prostate cancer (PC). MYC protein abundance is also increased in the majority of cases of advanced and metastatic castrate-resistant PC (mCRPC). Accordingly, the MYC-directed transcriptional program directly contributes to PC by upregulating the expression of a number of pro-tumorigenic factors involved in cell growth and proliferation. A key cellular process downstream of MYC activity is the regulation of ribosome biogenesis which sustains tumor growth. MYC activity also cooperates with the dysregulation of the phosphoinositol-3-kinase (PI3K)/AKT/mTOR pathway to promote PC cell survival. Recent advances in the understanding of these interactions through the use of animal models have provided significant insight into the therapeutic efficacy of targeting MYC activity by interfering with its transcriptional program, and indirectly by targeting downstream cellular events linked to MYC transformation potentialen_AU
dc.description.sponsorshipThis work was supported by Cancer Australia (CA 1084546 to Ross D. Hannan, Richard B. Pearson, and Luc Furic); Prostate Cancer Foundation of Australia (YI 0310 to Luc Furic and CG 1511 to Richard B. Pearson, Ross D. Hannan, and Luc Furic); National Health and Medical Research Council (Program Grant 1053792 and Project Grant 1004881 to R.B. Pearson and Ross D. Hannan; Senior Research Fellowships to Richard B. Pearson and Ross D. Hannan) and the Department of Health and Human Services acting through the Victorian Cancer Agency (MCRF16007 to Luc Furic).en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2073-4425en_AU
dc.identifier.urihttp://hdl.handle.net/1885/250490
dc.language.isoen_AUen_AU
dc.provenanceThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_AU
dc.publisherMDPI Open Access Publishingen_AU
dc.rights© 2017 by the authors; licensee MDPI, Basel, Switzerland.en_AU
dc.rights.licenseCreative Commons Attribution (CC BY) licenseen_AU
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_AU
dc.sourceGENESen_AU
dc.subjectMYCen_AU
dc.subjecttherapyen_AU
dc.subjectprostate canceren_AU
dc.subjectmouse modelsen_AU
dc.titleTherapeutic Approaches Targeting MYC-Driven Prostate Canceren_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue2en_AU
local.bibliographicCitation.lastpage16en_AU
local.bibliographicCitation.startpage1en_AU
local.contributor.affiliationRebello, Richard J, Monash Universityen_AU
local.contributor.affiliationPearson, Richard B, Peter MacCallum Cancer Centreen_AU
local.contributor.affiliationHannan, Ross, College of Health and Medicine, ANUen_AU
local.contributor.affiliationFuric, Luc, Monash Universityen_AU
local.contributor.authoruidHannan, Ross, u1000203en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor060405 - Gene Expression (incl. Microarray and other genome-wide approaches)en_AU
local.identifier.absfor111203 - Cancer Geneticsen_AU
local.identifier.ariespublicationa383154xPUB5255en_AU
local.identifier.citationvolume8en_AU
local.identifier.doi10.3390/genes8020071en_AU
local.identifier.scopusID2-s2.0-85013324844
local.identifier.thomsonID000399058000026
local.publisher.urlhttp://www.mdpi.com/journal/genesen_AU
local.type.statusPublished Versionen_AU

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