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Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex

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Date

2008

Authors

Fiedler, Marc
Sanchez-Barrena, Maria Jose
Nekrasov, Maxim
Mieszczanek, Juliusz
Rybin, Vladimir
Muller, Jurg
Evans, Phil
Bienz, Mariann

Journal Title

Journal ISSN

Volume Title

Publisher

Cell Press

Abstract

Pygo and BCL9/Legless transduce the Wnt signal by promoting the transcriptional activity of β-catenin/Armadillo in normal and malignant cells. We show that human and Drosophila Pygo PHD fingers associate with their cognate HD1 domains from BCL9/Legless t

Description

Keywords

Keywords: BCL9 protein; gene product; histone H3; lysine; PHD protein; Pygo protein; Wnt protein; article; crystal structure; Drosophila; gene silencing; genetic transcription; human; methylation; nonhuman; protein binding; Amino Acid Sequence; Animals; Binding Sit DNA; SIGNALING

Citation

URI

http://hdl.handle.net/1885/53937

Collections

ANU Research Publications

Source

Molecular Cell

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.molcel.2008.03.011

Restricted until

2037-12-31

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Description
01_Fiedler_Decoding_of_methylated_histone_2008.pdf (1.78 MB)

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