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Synthesis of (±)-Panduratin A and Related Natural Products Using the High Pressure Diels-Alder Reaction

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Authors

Pasfield, Luke A.
de la Cruz, Laura
Ho, Junming
Coote, Michelle
McLeod, Malcolm D.
Otting, Gottfried

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Publisher

Wiley

Abstract

Panduratin A and 4-hydroxypanduratin A are synthesised in 6 steps via a high pressure Diels-Alder reaction. This sequence has also allowed the synthesis of isopanduratin A, 4-hyrdoxyisopanduratin A, panduratin H, and panduratin I. In addition the regioselectivity of the Diels-Alder reaction has been investigated.

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Source

Asian Journal of Organic Chemistry

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Open Access

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Author/s accepted manuscript (AAM) / Post print