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Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes

Date

Authors

Lesage, Sylvie

Hartley, Suzanne

Akkaraju, Srinivas

Wilson, Judith

Townsend, Michelle

Goodnow, Christopher

Publisher

Rockefeller University Press

Abstract

Type 1 diabetes and other organ-specific autoimmune diseases often cluster together in human families and in congenic strains of NOD (nonobese diabetic) mice, but the inherited immuno-regulatory defects responsible for these diseases are unknown. Here we

Keywords

Keywords: autoantibody; CD4 antigen; immunoglobulin G antibody; immunoglobulin G1; major histocompatibility antigen; animal cell; animal model; article; autoimmune disease; autoimmunity; diabetes mellitus; disease predisposition; flow cytometry; genetic susceptibil Autoimmune disease; Clonal deletion; Diabetes mellitus type I; Genetic predisposition to disease; T lymphocytes

URI

http://hdl.handle.net/1885/94668

Collections

ANU Research Publications

Source

Journal of Experimental Medicine

Type

Journal article

DOI

10.1084/jem.20020735

Restricted until

2037-12-31

Downloads

File

Description

01_Lesage_Failure_to_censor_forbidden_2002.pdf (458 KB)