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Glutathione transferase zeta-catalyzed biotransformation of deuterated dihaloacetic acids

Date

Authors

Werkmeister, Jerome A

Anderson, Warwick P

Tzeng, Huey-Fen

Board, Philip

Anders, Michael

Publisher

Academic Press

Abstract

Glutathione transferase zeta (GSTZ) catalyzes the biotransformation of α-haloalkanoic acids. Treatment of rats or humans with dichloroacetic acid prolongs its elimination half-life, and preliminary studies in this laboratory show that fluorine-lacking, b

Keywords

Keywords: acetic acid derivative; deuterium; dichloroacetic acid; fluorine; glutathione transferase; glyoxylic acid; haloacid; isoenzyme; article; biotransformation; catalysis; half life time; human; nonhuman; priority journal; rat; Acetic Acids; Animals; Biotransf

URI

http://hdl.handle.net/1885/92532

Collections

ANU Research Publications

Source

Biochemical and Biophysical Research Communications

Type

Journal article

DOI

10.1006/bbrc.1999.1127

Restricted until

2037-12-31

Downloads

File

Description

01_Werkmeister_Glutathione_transferase_1999.pdf (63.29 KB)