Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity
Date
2010
Authors
Taddei, K.
Laws, S.M.
Verdile, G.
Munns, S.
D'Costa, K.
Harvey, A.R.
Martins, I.J.
Hill, F.
Levy, E.
Shaw, John
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Amyloid-β (Aβ) peptides play a central role in the pathogenesis of Alzheimer's disease. There is accumulating evidence that supports the notion that the toxicity associated with human Aβ (both 40 and 42) is dependent on its superoxide dismutase (SOD)-l
Description
Keywords
Keywords: 3 (4,5 dimethyl 2 thiazolyl) 2,5 diphenyltetrazolium bromide; amyloid beta protein inhibitor; amyloid beta protein[1-40]; amyloid beta protein[1-42]; clioquinol; hydrogen peroxide; lactate dehydrogenase; protein inhibitor; superoxide dismutase; unclassifi Beta amyloid; Drug development; Neutralization; Peptides; Phage display
Citation
Collections
Source
Neurobiology of Aging
Type
Journal article
Book Title
Entity type
Access Statement
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Restricted until
2037-12-31