Screening libraries for improved solubility: using E. coli dihydrofolate reductase as a reporter
Date
2013
Authors
Liu, Jian-Wei
Ollis, David
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Publisher
Humana Press Inc.
Abstract
Low protein solubility is a problem in many areas of protein science. Although chemical methods have been developed to solubilize proteins these are not always effective and add to the cost of producing the protein. One way of overcoming these difficultie
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Keywords
Keywords: dihydrofolate reductase; trimethoprim; antibiotic resistance; article; drug effect; enzymology; Escherichia coli; genetics; metabolism; solubility; Escherichia coli; Solubility; Tetrahydrofolate Dehydrogenase; Trimethoprim; Trimethoprim Resistance
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Source
Methods in Molecular Biology
Type
Journal article
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Restricted until
2037-12-31
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