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Selective modulation of different GABA(A) receptor isoforms by diazepam and etomidate in hippocampal neurons

Date

Authors

Seymour, Victoria

Curmi, John

Howitt, Susan

Casarotto, Marco

Laver, Derek Rowland

Tierney, Mary (Louise)

Publisher

Pergamon-Elsevier Ltd

Abstract

Diazepam modulation of native γ2-containing GABAA (γGABAA) receptors increases channel conductance by facilitating protein interactions involving the γ2-subunit amphipathic (MA) region, which is found in the cytoplasmic loop between transmembrane domai

Keywords

Keywords: 4 aminobutyric acid A receptor; diazepam; etomidate; gamma (392 422) MA peptide; peptide; unclassified drug; amino acid sequence; animal cell; article; brain nerve cell; controlled study; drug protein binding; female; hippocampus; ion conductance; male; n Amphipathic region; Diazepam; Etomidate; GABAA receptor; Ion channel; Protein interactions; Single-channel recording

URI

http://hdl.handle.net/1885/54700

Collections

ANU Research Publications

Source

The International Journal of Biochemistry and Cell Biology

Type

Journal article

DOI

10.1016/j.biocel.2012.06.001

Restricted until

2037-12-31

Downloads

File

Description

01_Seymour_Selective_modulation_of_2012.pdf (1.16 MB)