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A Semisynthetic Glutathione Peroxidase with High Catalytic Efficiency: Selenoglutathione Transferase

Date

Authors

Ren, Xiaojun

Jemth, Per

Board, Philip

Luo, Guimin

Mannervik, Bengt

Liu, Junqiu

Zhang, Kerong

Shen, Jiacong

Publisher

Elsevier

Abstract

Glutathione peroxidase (GPX) protects cells against oxidative damage by catalyzing the reduction of hydroperoxides by glutathione (GSH). GPX therefore has potential therapeutic value as an antioxidant, but its pharmacological development has been limited

Keywords

Keywords: Antibodies, Monoclonal; Binding Sites; Catalysis; Comparative Study; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Hydrogen Peroxide; Kinetics; Oxidation-Reduction; Protein Engineering; Selenium; Serine; Substrate Specificity; Support, Non

URI

http://hdl.handle.net/1885/91457

Collections

ANU Research Publications

Source

Chemistry and Biology

Type

Journal article

DOI

10.1016/S1074-5521(02)00167-9

Restricted until

2037-12-31

Downloads

File

Description

01_Ren_A_Semisynthetic_Glutathione_2002.pdf (95.17 KB)

02_Ren_A_Semisynthetic_Glutathione_2002.pdf (95.17 KB)

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