RNA-binding proteins in Mendelian disease

Date

Authors

Castello, Alfredo

Fischer, Bernd

Hentze, Matthias

Preiss, Thomas

Publisher

Elsevier

Abstract

RNA-binding proteins (RBPs) control all aspects of RNA fate, and defects in their function underlie a broad spectrum of human pathologies. We focus here on two recent studies that uncovered the in vivo mRNA interactomes of human cells, jointly implicating

Keywords

Keywords: initiation factor 4E; messenger RNA; ribonucleoprotein; ribosome RNA; RNA binding protein; transfer RNA; 3' untranslated region; complex formation; genetic association; genetic disorder; HeLa cell; human; in vivo study; mass spectrometry; Mendelian diseas Disease genetics; Gene set enrichment; Interactome capture; Mass spectrometry; MRNA metabolism; Proteomics; RNA-binding domain; RNA-binding protein

URI

http://hdl.handle.net/1885/21002

Collections

ANU Research Publications

Source

Trends in Genetics

Type

Journal article

DOI

10.1016/j.tig.2013.01.004

Restricted until

2037-12-31

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File

Description

01_Castello_RNA-binding_proteins_in_2013.pdf (2.42 MB)