The McGill Brisbane Symptom Score in relation to survival in pancreatic adenocarcinoma: a validation study
Date
2016-07
Authors
Doi, Suhail A R
Furuya-Kanamori, Luis
Engel, Jessica M
Jamal, Mohammad H
Stankowski, Rachel V
Barkun, Jeffrey
Onitilo, Adedayo A
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Verlag
Abstract
PURPOSE The McGill Brisbane Symptom Score (MBSS) is a clinical score for pancreatic cancer patients upon initial presentation that takes into account four variables (weight loss, abdominal pain, jaundice, and history of smoking) to stratify them into two MBSS intensity categories. Several studies have suggested that these categories are strongly associated with eventual survival in patients with resectable (rPCa) and unresectable (uPCa) pancreatic cancer. This study aimed to validate the MBSS in a cohort of patients with pancreatic cancer from a single institution. METHODS Survival time by resection status and MBSS intensity category were analyzed among 633 patients from our institution between 2001 and 2010. Hazard ratios for death using Cox proportional hazards models, with age as the timescale, adjustment for sex and year of diagnosis, and stratified by adjuvant chemotherapy status were estimated. RESULTS Median survival time was the longest in patients with low-intensity MBSS and rPCa (817 days), whereas the shortest survival time was found among patients with uPCa regardless of MBSS status (144-147 days). After consideration of age and chemotherapy status, high-intensity MBSS was associated with poorer survival for both rPCa (HR 1.64; 95 % CI 1.07-2.52) and uPCa (HR 1.35; 95 % CI 1.06-1.72). CONCLUSIONS Preoperative MBSS intensity is a useful prognostic indicator of survival in resectable as well as unresectable pancreatic cancer.
Description
Keywords
adenocarcinoma, mcgill brisbane symptom score, non-resectable, pancreatic neoplasms, resectable, unresectable, validation
Citation
Collections
Source
Cancer Causes and Control
Type
Journal article
Book Title
Entity type
Access Statement
Open Access