Nitric oxide synthase activity in adrenocorticotrophin-induced hypertension in the rat
Date
2001
Authors
Turner, Steven
Mangos, George
Whitworth, Judith
Journal Title
Journal ISSN
Volume Title
Publisher
Blackwell Science Asia
Abstract
1. The nitric oxide (NO) system has been implicated in the pathogenesis of various forms of experimental hypertension. We studied nitric oxide synthase (NOS) activity as a possible indicator of NO production in adrenocorticotrophin (ACTH)-induced hypertension in the rat. 2. Haemodynamic, metabolic and biochemical parameters were examined in sham (saline)- and ACTH (100 μg/kg per day)-treated male Sprague-Dawley rats (n = 20). 3. Adrenocorticotrophin treatment increased systolic blood pressure, serum corticosterone, adrenal NOS activity and adrenal nitrate and nitrite concentrations and decreased bodyweight and plasma nitrate/nitrite. 4. Previous observations of diminished NO production in ACTH- and corticosterone-induced hypertension in the rat were confirmed, but could not be explained by reduced NOS activity in the present study.
Description
Keywords
Keywords: corticosterone; corticotropin; nitrate; nitric oxide synthase; nitrite; adrenal gland; animal experiment; animal model; animal tissue; article; biochemistry; blood level; controlled study; corticosterone blood level; enzyme activity; hemodynamic parameter Adrenocorticotrophic hormone; Blood pressure; Hypertension; Nitric oxide; Rats
Citation
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Source
Clinical and Experimental Pharmacology and Physiology
Type
Journal article