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Hydrolysis of the 5'- p -Nitrophenyl Ester of TMP by the Proofreading Exonuclease (ε) Subunit of Escherichia coli DNA Polymerase III

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Date

2002

Authors

Hamdan, Samir
Bulloch, Esther
Thompson, Phillip
Beck, Jennifer
Yang, Ji Yeon
Crowther, Jeffrey
Lilley, Penelope
Carr, Paul D
Ollis, David
Brown, Susan Elizabeth

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

The core of DNA polymerase III, the replicative polymerase in Escherichia coli, consists of three subunits (α, ε, and θ). The ε subunit is the 3′-5′ proofreading exonuclease that associates with the polymerase (α) through its C-terminal region an

Description

Keywords

Keywords: 4 nitrophenyl 3' thymidylate; 4-nitrophenyl 3'-thymidylate; divalent cation; DNA directed DNA polymerase gamma; drug derivative; exodeoxyribonuclease; exodeoxyribonuclease V; magnesium; manganese; thymidine phosphate; ester derivative; exonuclease; magnes

Citation

URI

http://hdl.handle.net/1885/91445

Collections

ANU Research Publications

Source

Biochemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/bi0159480

Restricted until

2037-12-31

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