Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance
Date
2009
Authors
Parish, Ian
Waithman, Jason
Davey, Gayle M
Belz, Gabrielle
Mintern, Justine
Kurts, Christian
Sutherland, Robyn
Carbone, Francis
Heath, William R
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Volume Title
Publisher
National Academy of Sciences (USA)
Abstract
Autoimmune diseases tend to be chronic and progressive, but how these responses are sustained is not clear. One cell type that might contribute to autoimmunity is the cytotoxic T lymphocyte (CTL), which, as a consequence of causing tissue destruction and
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Keywords
Keywords: autoantigen; gamma interferon; adaptive immunity; adoptive transfer; animal cell; animal tissue; antigen presentation; apoptosis; article; autoimmunity; CD8+ T lymphocyte; chimera; controlled study; cross presentation; cytokine production; cytotoxic T lym Antigen presentation; Apoptosis; Autoimmunity; CTL; T cell
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PNAS - Proceedings of the National Academy of Sciences of the United States of America
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Journal article
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2037-12-31
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