Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance

Date

2009

Authors

Parish, Ian
Waithman, Jason
Davey, Gayle M
Belz, Gabrielle
Mintern, Justine
Kurts, Christian
Sutherland, Robyn
Carbone, Francis
Heath, William R

Journal Title

Journal ISSN

Volume Title

Publisher

National Academy of Sciences (USA)

Abstract

Autoimmune diseases tend to be chronic and progressive, but how these responses are sustained is not clear. One cell type that might contribute to autoimmunity is the cytotoxic T lymphocyte (CTL), which, as a consequence of causing tissue destruction and

Description

Keywords

Keywords: autoantigen; gamma interferon; adaptive immunity; adoptive transfer; animal cell; animal tissue; antigen presentation; apoptosis; article; autoimmunity; CD8+ T lymphocyte; chimera; controlled study; cross presentation; cytokine production; cytotoxic T lym Antigen presentation; Apoptosis; Autoimmunity; CTL; T cell

Citation

Source

PNAS - Proceedings of the National Academy of Sciences of the United States of America

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

Restricted until

2037-12-31