Skeletal muscle mass in relation to 10 year cardiovascular disease incidence among middle aged and older adults: The ATTICA study
Date
2020
Authors
Tyrovolas, Stefanos
Panagiotakos, Demosthenes B.
Georgousopoulou, Ekavi
Chrysohoou, Christina
Tousoulis, Dimitrios
Haro, J. M.
Pitsavos, Christos
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British Medical Association
Abstract
Background Skeletal muscle mass (SMM) is inversely
associated with cardiometabolic health and the ageing
process. The aim of the present work was to evaluate
the relation between SMM and 10 year cardiovascular
disease (CVD) incidence, among CVD-free adults 45+
years old.
Methods ATTICA is a prospective, population-based
study that recruited 3042 adults without pre-existing
CVD from the Greek general population (Caucasians;
age ≥18 years; 1514 men). The 10 year study follow-up
(2011�2012) captured the fatal/non-fatal CVD incidence
in 2020 participants (50% men). The working sample
consisted of 1019 participants, 45+ years old (men:
n=534; women: n=485). A skeletal muscle mass index
(SMI) was created to reflect SMM, using appendicular
skeletal muscle mass (ASM) standardised by body mass
index (BMI). ASM and SMI were calculated with specific
indirect population formulas.
Results The 10 year CVD incidence increased
significantly across the baseline SMI tertiles (p<0.001).
Baseline SMM showed a significant inverse association
with the 10 year CVD incidence (HR 0.06, 95%CI 0.005
to 0.78), even after adjusting for various confounders.
Additionally, participants in the highest SMM tertile had
81% (95% CI 0.04 to 0.85) lower risk for a CVD event
as compared with those in the lowest SMM tertile.
Conclusions The presented findings support the
importance of SMM evaluation in the prediction of
long-term CVD risk among adults 45+ years old without
pre-existing CVD. Preservation of SMM may contribute to
CVD health.
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Journal of Epidemiology and Community Health
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Journal article
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Open Access
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