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Effects of pentobarbital on GABA-activated currents in acutely-isolated rat dentate gyrus granule neurons

Date

Authors

Lim, Michelle

Lindquist, C E L

Birnir, Bryndis

Publisher

Elsevier

Abstract

Granule neurons from the rat dentate gyrus were acutely isolated and whole-cell currents recorded. Maximal enhancement of 7 μM γ-aminobutyric acid (GABA; EC30) evoked currents was obtained with 100 μM pentobarbital where the peak-current was 2.1±0.2 o

Keywords

Keywords: 4 aminobutyric acid; 4 aminobutyric acid A receptor; ion channel; pentobarbital; animal tissue; article; concentration response; controlled study; dentate gyrus; drug effect; granule cell; nerve cell; nerve potential; nonhuman; patch clamp; priority journ ?-aminobutyric acidA; Barbiturates; Hippocampus; Inhibition; Ion channel; Receptor

URI

http://hdl.handle.net/1885/77198

Collections

ANU Research Publications

Source

Neuroscience Letters

Type

Journal article

DOI

10.1016/j.neulet.2003.09.025

Restricted until

2037-12-31

Downloads

File

Description

01_Lim_Effects_of_pentobarbital_on_2003.pdf (101.5 KB)