Bridgehead Arylation: A Direct Route to Advanced Intermediates for the Synthesis of C-20 Diterpene Alkaloids

Williams, Craig; Mander, Lewis

Bridgehead Arylation: A Direct Route to Advanced Intermediates for the Synthesis of C-20 Diterpene Alkaloids

Date

2003

Authors

Williams, Craig

Mander, Lewis

Publisher

American Chemical Society

Abstract

Equation presented. Rapid access to the ABCE ring system of the C 20 diterpene alkaloids was achieved by silver(I)-promoted intramolecular Friedel-Crafts arylation of a functional group-specific 5-bromo-3-azabicyclo[3.3.1]nonane derivative.

Keywords

Keywords: alkaloid derivative; alkane derivative; carbon; silver; article; arylation; chemical reaction; chemical structure; drug structure; drug synthesis; Friedel crafts arylation; Acylation; Alkaloids; Aza Compounds; Bridged Compounds; Bromides; Catalysis; Cycli

URI

http://hdl.handle.net/1885/88379

Collections

ANU Research Publications

Source

Organic Letters

Type

Journal article

DOI

10.1021/ol0353060

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Bridgehead Arylation: A Direct Route to Advanced Intermediates for the Synthesis of C-20 Diterpene Alkaloids

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