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Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines: Implications for future trials

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Date

2006

Authors

De Rose, Robert
Sullivan, Mark T
Dale, C Jane
Kelleher, Anthony D
Emery, Sean
Cooper, David A.
Ramshaw, Ian
Boyle, David B
Kent, Stephen J

Journal Title

Journal ISSN

Volume Title

Publisher

Landes Bioscience

Abstract

Estimating effective doses of novel HIV vaccines is challenging. Dose-response analyses of DNA and fowlpox virus HIV vaccines showed that 1 mg of DNA vaccine and 5 × 107 pfu of fowlpox virus booster was immunogenic in macaques. However, this dose was poo

Description

Keywords

Keywords: DNA vaccine; gamma interferon; Human immunodeficiency virus vaccine; recombinant vaccine; article; cellular immunity; clinical trial; dose response; drug clearance; enzyme immunoassay; enzyme linked immunospot assay; Fowlpox virus; human; immunogenicity; Body surface area; Immunologic dose-response relationship; Prime-boost; Vaccine

Citation

URI

http://hdl.handle.net/1885/85199

Collections

ANU Research Publications

Source

Human Vaccines

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

Restricted until

2037-12-31

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01_De Rose_Dose-response_relationship_of_2006.pdf (252.71 KB)

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