Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages

Volkmann, Lars; Bain, Odile; Saeftel, Michael; Specht, Sabine; Fischer, Kerstin; Brombacher, Frank; Matthaei, Klaus; Hoerauf, Achim

Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages

Date

2003

Authors

Volkmann, Lars

Bain, Odile

Saeftel, Michael

Specht, Sabine

Fischer, Kerstin

Brombacher, Frank

Matthaei, Klaus

Hoerauf, Achim

Publisher

Springer

Abstract

We compared the impact of IL-4 and IL-5 deficiency during the fully permissive infection of BALB/c mice with the rodent filaria Litomosoides sigmodontis. IL-5, in contrast to IL-4, is crucial for the containment of adult worms during short- and long-term

Keywords

Keywords: interleukin 4; interleukin 4 receptor; interleukin 5; animal cell; animal experiment; animal model; conference paper; controlled study; eosinophil; female; filariasis; infection sensitivity; inflammation; knockout mouse; male; microfilariasis; mouse; neut Eosinophils; Interleukin-4; Interleukin-5; Murine filariasis; Neutrophils

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http://hdl.handle.net/1885/88534

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ANU Research Publications

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Medical Microbiology and Immunology

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Journal article

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Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages

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