Expression of the heparan sulfate-degrading enzyme heparanase is induced in infiltrating CD4+ T cells in experimental autoimmune encephalomyelitis and regulated at the level of transcription by early growth response gene 1

de Mestre, A; Staykova, Maria; Hornby, June; Willenborg, D; Hulett, Mark

Expression of the heparan sulfate-degrading enzyme heparanase is induced in infiltrating CD4+ T cells in experimental autoimmune encephalomyelitis and regulated at the level of transcription by early growth response gene 1

Date

2007

Authors

de Mestre, A

Staykova, Maria

Hornby, June

Willenborg, D

Hulett, Mark

Publisher

Federation of American Societies for Experimental Biology

Abstract

The heparan sulfate-cleaving enzyme heparanase (HPSE) plays an important role in remodeling of the basement membrane and extracellular matrix during inflammation. Inducible HPSE enzymatic activity has been reported in leukocytes; however, little is known