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KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria

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dc.contributor.authorHortle, Elinor
dc.contributor.authorStarrs, Lora
dc.contributor.authorBrown, Fiona G.
dc.contributor.authorJane, Sephen M
dc.contributor.authorCurtis, David J
dc.contributor.authorMcMorran, Brendan
dc.contributor.authorFoote, Simon
dc.contributor.authorBurgio, Gaetan
dc.date.accessioned2022-11-29T02:55:27Z
dc.date.available2022-11-29T02:55:27Z
dc.date.issued2019
dc.date.updated2021-11-28T07:29:43Z
dc.description.abstractPlasmodium falciparum malaria causes half a million deaths per year, with up to 9% of this mortality caused by cerebral malaria (CM). One of the major processes contributing to the development of CM is an excess of host inflammatory cytokines. Recently K+ signaling has emerged as an important mediator of the inflammatory response to infection; we therefore investigated whether mice carrying an ENU induced activation of the electroneutral K+ channel KCC1 had an altered response to Plasmodium berghei. Here we show that KCC1(M935K/M935K )mice are protected from the development of experimental cerebral malaria, and that this protection is associated with an increased CD4+ and TNFa response. This is the first description of a K+ channel affecting the development of experimental cerebral malaria.en_AU
dc.description.sponsorshipWe would like to acknowledge Shelley Lampkin and Australian Phenomics Facility (APF) for the maintenance of the mouse colonies. Tis study was funded by the National Health and Medical Research Council of Australia (Program Grant 490037, and Project Grants 605524 and APP1047090), the National Collaborative Research Infrastructure Strategy (NCRIS), the Education Investment Fund from the Department of Education and Training, the Australian Phenomics Network, Howard Hughes Medical Institute and the Bill and Melinda Gates Foundation.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2045-2322en_AU
dc.identifier.urihttp://hdl.handle.net/1885/281320
dc.language.isoen_AUen_AU
dc.provenanceThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en_AU
dc.publisherNature Publishing Groupen_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/490037en_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/605524en_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1047090en_AU
dc.rights© The Author(s) 2019en_AU
dc.rights.licenseCreative Commons Attribution 4.0 International Licenseen_AU
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_AU
dc.sourceScientific Reportsen_AU
dc.titleKCC1 Activation protects Mice from the Development of Experimental Cerebral Malariaen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue6356en_AU
local.bibliographicCitation.lastpage11en_AU
local.bibliographicCitation.startpage1en_AU
local.contributor.affiliationHortle, Elinor, College of Health and Medicine, ANUen_AU
local.contributor.affiliationStarrs, Lora, College of Health and Medicine, ANUen_AU
local.contributor.affiliationBrown, Fiona G., Monash Universityen_AU
local.contributor.affiliationJane, Sephen M, Royal Melbourne Hospitalen_AU
local.contributor.affiliationCurtis, David J, Monash Universityen_AU
local.contributor.affiliationMcMorran, Brendan, College of Health and Medicine, ANUen_AU
local.contributor.affiliationFoote, Simon, College of Health and Medicine, ANUen_AU
local.contributor.affiliationBurgio, Gaetan, College of Health and Medicine, ANUen_AU
local.contributor.authoruidHortle, Elinor, u1002702en_AU
local.contributor.authoruidStarrs, Lora, u4301798en_AU
local.contributor.authoruidMcMorran, Brendan, u5267721en_AU
local.contributor.authoruidFoote, Simon, u5697711en_AU
local.contributor.authoruidBurgio, Gaetan, u5727247en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor320102 - Haematologyen_AU
local.identifier.absfor320211 - Infectious diseasesen_AU
local.identifier.absfor320407 - Innate immunityen_AU
local.identifier.absseo280103 - Expanding knowledge in the biomedical and clinical sciencesen_AU
local.identifier.absseo200105 - Treatment of human diseases and conditionsen_AU
local.identifier.ariespublicationu3102795xPUB2020en_AU
local.identifier.citationvolume9en_AU
local.identifier.doi10.1038/s41598-019-42782-xen_AU
local.identifier.scopusID2-s2.0-85064891997
local.identifier.thomsonID4.6521E+11
local.publisher.urlhttps://www.nature.com/en_AU
local.type.statusPublished Versionen_AU

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