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Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine cores

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Date

2001

Authors

Wang, Gary
Chen, Yuanwei
Wang, Sheldon
Gentles, Andrew J
Sowin, Thomas
Kati, Warren
Muchmore, Steven
Giranda, Vincent
Stewart, Kent
Sham, Hing

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

The discovery of (±)-(2S,3R,4R)-2-(trifluoroacetamido)methyl-3-amino-1- (N′-ethyl-N′-isopropylcarbamyl)pyrrolidine-4-carboxylic acid (A-192558, 20e) as a potent inhibitor of influenza neuraminidase (NA) is described. Efficient syntheses of two core s

Description

Keywords

Keywords: 2 (trifluoroacetamido)methyl 3 amino 1 (n' ethyl n' isopropylcarbamyl)pyrrolidine 4 carboxylic acid; a 87380; pyrrolidine derivative; sialidase inhibitor; unclassified drug; zanamivir; article; conformational transition; drug design; drug structure; drug

Citation

URI

http://hdl.handle.net/1885/94122

Collections

ANU Research Publications

Source

Journal of Medicinal Chemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/jm000468c

Restricted until

2037-12-31

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01_Wang_Design,_Synthesis,_and_2001.pdf (457.3 KB)

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