Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA A receptors

Date

Authors

Karim, Nasiara

Curmi, John

Gavande, Navnath

Johnston, Graham A R

Hanrahan, Jane R

Tierney, Mary (Louise)

Chebib, Mary

Publisher

Nature Publishing Group

Abstract

BACKGROUND AND PURPOSE Flavonoids are known to have anxiolytic and sedative effects mediated via actions on ionotropic GABA receptors. We sought to investigate this further. EXPERIMENTAL APPROACH We evaluated the effects of 2′-methoxy-6-methylflavone (2

Keywords

Keywords: 2' methoxy 6 methylflavone; 3 amino 2 (3 carboxypropyl) 6 (4 methoxyphenyl)pyridazinium bromide; 4 aminobutyric acid; 4 aminobutyric acid A receptor; 4 aminobutyric acid A receptor alpha2beta2; anxiolytic agent; barbituric acid derivative; bicuculline; ch a1- and a2-containing GABA A receptors; anxiolytic agents; dissociated hippocampal neurons; flavonoids; GABA (?-aminobutyric acid); GABA A receptors; sedative effects; Xenopus oocytes

URI

http://hdl.handle.net/1885/32783

Collections

ANU Research Publications

Source

British Journal of Pharmacology

Type

Journal article

DOI

10.1111/j.1476-5381.2011.01604.x

Restricted until

2037-12-31

Downloads

File

Description

01_Karim_2'-Methoxy-6-methylflavone:_A_2012.pdf (138.52 KB)

02_Karim_2'-Methoxy-6-methylflavone:_A_2012.pdf (826.07 KB)

03_Karim_2'-Methoxy-6-methylflavone:_A_2012.pdf (1.05 MB)