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IDENTIFICATION AND CHARACTERIZATION OF THE ZETA CLASS OF GLUTATHIONE TRANSFERASES

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Date

2000

Authors

Board, Philip
Chelvanayagam, Gareth
Jermiin, Lars
Blackburn, Anneke

Journal Title

Journal ISSN

Volume Title

Publisher

Gordon and Breach

Abstract

A new class of glutathione transferase isoenzymes has been identified by sequence data base analysis. The Zeta class isoenzymes occur in a wide range of species including plants, insects and mammals. The human enzyme has been shown to catalyse the glutathione dependent transformation of dichloroacetic acid to glyoxylic acid and the isomerization of maleylacetoacetate to fumarylacetoacetate. The latter reaction is an essential step in the catabolism of tyrosine. The GSTZ1 gene is composed of 9 exons that extend over 10.9 kb and has been localized to chromosome 14q24.3.

Description

Keywords

Keywords: acetic acid derivative; dichloroacetic acid; fumaric acid derivative; glutathione transferase; glyoxylic acid; isoenzyme; maleic acid derivative; tyrosine; chromosome 14q; chromosome map; conference paper; data base; gene library; human; nonhuman; nucleot Glutathione transferase zeta

Citation

URI

http://hdl.handle.net/1885/90397

Collections

ANU Research Publications

Source

Clinical Chemistry and Enzymology Communications

Type

Journal article

Book Title

Entity type

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DOI

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