Variation in MS outcome

Abstract

The course of multiple sclerosis (MS) is highly variable, manifest by a wide range in age at onset, either relapsing or progressive course from onset, and major differences in attack severity and recovery.1 Not surprisingly, the rate and age at which severe and permanent disabilities are attained are also highly variable. Most of these descriptors of outcome are generally considered independently of one another, as are the clinical and radiologic features of disease; however, certain features cluster and may define unique subtypes of CNS demyelinating disease.