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Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice

Date

Authors

Ip, Emilia

Farrell, Geoffrey

Robertson, Graham

Hall, Pauline

Kirsch, Richard

Leclercq, Isabelle

Publisher

W B Saunders Co

Abstract

We have proposed that steatohepatitis results from reactive oxygen species (ROS) acting on accumulated fatty acids to form proinflammatory lipoperoxides. Cytochrome P450 4a (Cyp4a) and Cyp2e1 are potential hepatic sources of ROS. We tested the hypothesis

Keywords

Keywords: alkane 1 monooxygenase; cell receptor; Cyp4a14 protein, mouse; cytochrome P450; fatty acid; hypocholesterolemic agent; methionine; mixed function oxidase; pirinixic acid; pyrimidine derivative; reactive oxygen metabolite; transcription factor; triacylglyc

URI

http://hdl.handle.net/1885/33908

Collections

ANU Research Publications

Source

Hepatology

Type

Journal article

DOI

10.1053/jhep.2003.50307

Restricted until

2037-12-31

Downloads

File

Description

01_Ip_Central_role_of_2003.pdf (335.67 KB)